July 22, 1974

Medical News

JAMA. 1974;229(4):375-387. doi:10.1001/jama.1974.03230420001001

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'Diabetes virus' search continues though Coxsackie B4 is cleared  Ever since the 1869 report of "A Case of Diabetes Mellitus Quickly Following Mumps," investigators have been trying to establish an etiologic role for acute viral infections in the pathogenesis of diabetes mellitus. Epidemiologic studies have implicated diabetes as a sequel of Coxsackie virus B type 4 infection, rubella, and mumps. Two reports at the Atlanta meeting of the American Diabetes Association may have "cleared" Coxsackie B4 of suspicion while describing a new animal model of Venezuelan equine encephalitis virus that should shed more light on how viruses affect the pancreas."Evidence does not support the concept that Coxsackie B4 causes diabetes," said Stephen E. Dippé, MD, associate chief of the Southwestern Field Studies Section of the National Institute of Arthritis, Metabolism, and Digestive Diseases, in Phoenix, Ariz. Dr. Dippé and his associates studied 335 Aleut residents of the isolated