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July 29, 1974

Scleroderma and Mosquitos

Author Affiliations

Columbia-Presbyterian Medical Center New York

JAMA. 1974;229(5):519. doi:10.1001/jama.1974.03230430013004

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To the Editor.—  A patient of mine with skin biopsy-proven scleroderma reports an interesting observation. During the summer of 1973, when there was a heavy influx of mosquitos in her section of Queens, NY, she alone, among her family and friends, was totally immune from mosquito bites.Of further interest is her family history: Her sister and mother both have the Ehlers-Danlos syndrome, with hyperelastic skin, hyperextendable joints, bossing of the skull, and "cigaret-paper" scars of the knees and forehead. Her mother is the offspring of a first-cousin marriage. Karyotyping of all three individuals failed to reveal any gross chromosomal abnormalities.