July 29, 1974

Dry Mouth and Dysglycemia

Author Affiliations

University of Alabama Birmingham

JAMA. 1974;229(5):523. doi:10.1001/jama.1974.03230430017016

To the Editor.—  Occasional published reference has been made concerning the relationship between diabetes mellitus and xerostomia (dry mouth).Conner et al1 have studied this relationship in a more quantitative fashion. They reported recently that parotid salivary flow in an age- and sexmatched sample of 30 diabetics and 30 nondiabetics is significantly different. The mean parotid flow in the diabetics was only one-fourth that of the controls, and the statistical significance of the mean difference in flow rate was less than the 1% confidence level (P<.01).Scant attention, however, has been given to the possible association of xerostomia and overall carbohydrate metabolism (hyperglycemia, normoglycemia, and hypoglycemia).2 Considering these three aspects of glycemia, there appears to be a distinct correlation between xerostomia and dysglycemia, both hyperglycemia and hypoglycemia (J Am Geriatr Soc 12:337, 1964).In an age- and sex-paired analysis of 38 subjects, a classic three-hour glucose tolerance