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November 14, 1977

Unusual Cause of Acute AbdomenSickle Cell Trait and Nonhypoxic Splenic Infarction

Author Affiliations

From the Departments of Pathology (Drs King and Hirose), Radiology (Dr Lindstrom), and Surgery (Drs State and Schwartz), Harbor General Hospital, University of California at Los Angeles School of Medicine, Torrance.

JAMA. 1977;238(20):2173-2174. doi:10.1001/jama.1977.03280210065026

Splenic infarction under hypoxic conditions is a well-known complication of sickle cell trait (Hgb AS). However, this case illustrates that it may occur without any clinical conditions or circumstances associated with decreased Pao2. In addition, sickle cell trait should be included in the differential diagnoses of splenic infarction even if the patient is not of African ancestry.

(JAMA 238:2173-2174, 1977)