Splenic infarction under hypoxic conditions is a well-known complication of sickle cell trait (Hgb AS). However, this case illustrates that it may occur without any clinical conditions or circumstances associated with decreased Pao2. In addition, sickle cell trait should be included in the differential diagnoses of splenic infarction even if the patient is not of African ancestry.
(JAMA 238:2173-2174, 1977)
King DT, Lindstrom RR, State D, Hirose FM, Schwartz A. Unusual Cause of Acute AbdomenSickle Cell Trait and Nonhypoxic Splenic Infarction. JAMA. 1977;238(20):2173–2174. doi:10.1001/jama.1977.03280210065026