Eight healthy men each received five different oral digoxin (Lanoxin) preparations in single-dose multicrossover studies. Preparations used were digoxin elixir, two tablets with rapid in vitro dissolution, and two slow-dissolution tablets. Bioavailability was determined from area under the eighthour serum concentration curve and six-day cumulative urinary excretion of digoxin.
There was no significant difference in bioavailability among elixir and rapid-dissolution tablets. Slow-dissolution tablets were less bioavailable than the other three preparations. Rapid-dissolution tablets and liquid preparations of digoxin can be used interchangeably in most clinical situations.
(JAMA 229:1774-1776, 1974)
Greenblatt DJ, Duhme DW, Koch-Weser J, Smith TW. Equivalent Bioavailability From Digoxin Elixir and Rapid-Dissolution Tablets. JAMA. 1974;229(13):1774-1776. doi:10.1001/jama.1974.03230510048022