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September 23, 1974

Equivalent Bioavailability From Digoxin Elixir and Rapid-Dissolution Tablets

Author Affiliations

From the Clinical Pharmacology Unit (Drs. Greenblatt, Duhme, and Koch-Weser) and the Cardiac Unit (Dr. Smith), Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston.

JAMA. 1974;229(13):1774-1776. doi:10.1001/jama.1974.03230510048022

Eight healthy men each received five different oral digoxin (Lanoxin) preparations in single-dose multicrossover studies. Preparations used were digoxin elixir, two tablets with rapid in vitro dissolution, and two slow-dissolution tablets. Bioavailability was determined from area under the eighthour serum concentration curve and six-day cumulative urinary excretion of digoxin.

There was no significant difference in bioavailability among elixir and rapid-dissolution tablets. Slow-dissolution tablets were less bioavailable than the other three preparations. Rapid-dissolution tablets and liquid preparations of digoxin can be used interchangeably in most clinical situations.

(JAMA 229:1774-1776, 1974)