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October 12, 1970

Urine Testing Schedules in Methadone Maintenance Treatment of Heroin Addiction

Author Affiliations

From the Department of Pharmacology and the Division of Biostatistics, Department of Community and Preventive Medicine, Stanford (Calif) University School of Medicine, and the Santa Clara County Methadone Program, San Jose, Calif.

JAMA. 1970;214(2):311-315. doi:10.1001/jama.1970.03180020031006

In the treatment of heroin addiction by methadone hydrochloride maintenance, it is customary to test urine specimens regularly, in order to monitor each patient's illicit use of drugs and to assess the general success of the program. Principles and graphs are presented here to aid the physician in choosing an economical testing frequency, and in interpreting the results quantitatively on a correct statistical basis. For most purposes, a random testing schedule at an average frequency of once in five days will suffice.