[Skip to Content]
[Skip to Content Landing]
Article
October 14, 1974

Long-Term Anticoagulant Therapy After Myocardial Infarction

JAMA. 1974;230(2):208-209. doi:10.1001/jama.1974.03240020016007

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.

Abstract

To the Editor.—  The place of anti-coagulant therapy for a prolonged period after recovery from acute myocardial infarction is still controversial. A randomized clinical trial of this treatment conducted at the Bronx Municipal Hospital Center, while essentially negative, studied 243 men and 85 women who had recovered from acute myocardial infarction; they were followed up for one to three years. All except 20 patients had participated in the study of anticoagulant therapy for acute myocardial infarction previously reported (222:541, 1972). Those treated with anticoagulants during the period of hospitalization after acute myocardial infarction were randomly divided at the time of discharge into three groups: (1) continuous therapy with anticoagulants for the duration of the study; (2) anticoagulant treatment for one year, then abrupt termination for the remainder of the study; and (3) control, no anticoagulant therapy.An unrandomized group (group 4) (54 men, 13 women), not treated with anticoagulants in

×