January 2, 1978

Needle Aspiration Biopsy: A Critical AppraisalEight Years and 3,267 Specimens Later

Author Affiliations

From the Departments of Pathology (Dr Kline) and Surgery (Dr Neal), Lakenau Hospital, Philadelphia.

JAMA. 1978;239(1):36-39. doi:10.1001/jama.1978.03280280036021

Fine-needle aspiration biopsy was used to diagnose lesions from the breast, subcutaneous nodules and lymph nodes, prostate, deep masses, lung, and pancreas. Over an eight-year period, 3,267 specimens were examined. The biopsy specimens were taken with 18- to 22-gauge disposable needles with attached syringes, were fixed immediately, and were stained according to the method of Papanicolaou. Frequently, the aspiration was done as an office procedure. The method was essentially complicationfree. The biopsy specimen was easy to interpret, and the procedure had an overall accuracy of approximately 90%. It should be used by all clinicians, especially on the initial visit of the patient.

(JAMA 239:36-39, 1978)