[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
October 21, 1974

Hyperlipemia During Estrogen Therapy

Author Affiliations

Harbor General Hospital Torrance, Calif

JAMA. 1974;230(3):373-374. doi:10.1001/jama.1974.03240030015010

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


To the Editor.—  We would like to reply to the letters published in the May 13, 1974, issue of The Journal concerning our article, "Massive Hyperlipemia During Estrogen Therapy" (227:522, 1974).As Dr. Applegate suggested, certainly caloric intake, the degree of saturated and unsaturated fats in the diet, ethanol, and free sugar intake are all very important determinants of serum cholesterol and triglyceride levels (Kuo PT, Ann Intern Med 68:449, 1968; Bortz WM, Metabolism 22:1507, 1973: Ginsberg H, et al, Ann Intern Med 80:143, 1974; Fredrickson DS, et al, N Engl J Med 276:32, 1967). While we do not deny the effects of weight loss and reduction of carbohydrates and saturated-fat intake in our cases 2 and 3, the decline in lipid levels from the extremely high levels in all four cases (especially cases 1 and 4, on whom no dietary restrictions were placed), when estrogen therapy was discontinued, to