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November 23, 1970

A Practical Guide to Drug Usage in Adult Patients With Impaired Renal Function

Author Affiliations

From the Renal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston. Dr. Bennett is now with the Renal Unit, Department of Medicine, Hospital of the University of Oregon, Portland. Dr. Singer is now with the Renal-Electrolyte Section, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia.

JAMA. 1970;214(8):1468-1475. doi:10.1001/jama.1970.03180080050010

Four tables describe maintenance dosage intervals for common therapeutic agents used in patients with renal disease. Particular emphasis has been given to the use of biological half-life and creatinine clearance for modification of the usual dose schedules, and to the adjustments required by patients undergoing dialysis. Toxic effects that relate directly to drug usage in patients with renal failure are also described.