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To the Editor.—
While the Council on Drugs is correct in joining those who decry the use of irrational drug combination products, there is a very real danger that zeal to remove combinations from the market will lead to "throwing the baby out with the bath water." The ambulatory treatment of hypertensive patients is an area in which it would be particularly unwise to eliminate drug combinations from the market. Many hypertensive patients require more than one drug for control, and the more different types of pill the patient must take the greater the chance that he will become confused about dosage, or will give up the attempt to take his medicine faithfully. A simplified antihypertensive treatment program to which a patient will adhere faithfully is far better than a program which is ideal but confusing, and which he simply cannot follow.
Gillette RD. Irrational Drug Combination Products. JAMA. 1970;214(8):1565. doi:10.1001/jama.1970.03180080145034