In seven consecutive melanoma-prone families, pigmented lesions with distinctive clinical and histologic characteristics occurred in 18 of 20 melanoma patients (90%) and 24 of 43 first-degree relatives (56%). Recognition of these lesions led to the detection of early-stage melanoma in six family members. This syndrome appears to represent an autosomal dominant trait and may serve as a cutaneous marker to identify persons at high risk for melanoma.
(JAMA 239:744-746, 1978)
Reimer RR, Clark WH, Greene MH, Ainsworth AM, Fraumeni JF. Precursor Lesions in Familial MelanomaA New Genetic Preneoplastic Syndrome. JAMA. 1978;239(8):744-746. doi:10.1001/jama.1978.03280350068019