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December 7, 1970

Primary Drug Resistance In Tuberculosis

Author Affiliations

Washington, DC

JAMA. 1970;214(10):1887-1888. doi:10.1001/jama.1970.03180100077022

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To the Editor:—  It is apparent that Doctors Tizes and Zaki have strong feelings on the problem of primary drug resistance in tuberculosis. Unfortunately, they state their criticisms of the opinions expressed in the editorial on this topic with use of some of the same arguments to which they object. All would agree with them that one cannot generalize on the matter of drug resistance but that is just what they do! Some surveys encompass national sampling, others deal with states, districts, towns, or special groups. For example, a prevalence of 40% of drug-resistant strains isolated from the inhabitants of skid row by Chaves and others (Amer Rev Resp Dis, 84:647, 1961) is not representative of New York city any more than the critics' finding of a "rise in infections with strains resistant to isoniazid from 6.5% in 1960 to 17.3% in 1964."Hobby and her associates (Amer Rev