To the Editor.—
Since the report of an edema-anemia-hypoproteinemia symptom complex in infants with cystic fibrosis (by Billie and Vahlquist Acta Pediatr 44:435, 1955), several articles have been published similar to that of Lee et al (228:585, 1974). We have also participated in the care of identical male twins with this interesting symptom complex and would like to comment on them.
Report of Cases.—Case 1.—
A 2,724-gm (6-lb) boy was born to unrelated parents following an uncomplicated 39-week gestation. Neonatal course was uncomplicated, and he was breast-fed without difficulty. Following the institution of milk supplementation, however, a diffuse, macular, erythematous rash appeared and a soy formula was given. One week later, he was "swollen and pale," and oral iron therapy was started. He did not improve, however, and at 4 weeks of age was pale and edematous. Vital signs were normal for age except for the marked pallor, edema,
Paxson CL, Lock J. Idiopathic Hypoproteinemia in Twins. JAMA. 1974;230(9):1257-1258. doi:10.1001/jama.1974.03240090017012