The unusual sensory and motor symptoms of the restless legs syndrome are described in general and as experienced by a 48-year-old woman with severe insomnia secondary to these symptoms. The neurologic evaluation of this patient showed definite evidence of motor neuron disease as reflected in abnormalities in the electromyogram, muscle biopsy specimen, and cerebrospinal fluid.
(JAMA 230:1302-1303, 1974)
Frankel BL, Patten BM, Gillin JC. Restless Legs SyndromeSleep-Electroencephalographic and Neurologic Findings. JAMA. 1974;230(9):1302-1303. doi:10.1001/jama.1974.03240090042025