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December 2, 1974

Mechanisms of Cell-Mediated Immunity

Author Affiliations

Duke University Medical Center Durham, NC

JAMA. 1974;230(9):1330. doi:10.1001/jama.1974.03240090066040

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This volume is intended to provide a comprehensive review of cell-mediated immune reactions, discussing direct as well as indirect roles of lymphocytes in classic delayed hypersensitivity reactions, transplantation immunity, and host responses to infections and tumors. Included in the book are 12 chapters covering various aspects of these subjects written by well-known researchers in their respective fields. While a number of selected topics are well developed, this volume suffers from the same limitations as would any other text on this subject. In such a rapidly developing field, the book is dated soon after publication.

Two chapters are presented on in vitro characterizations (Remold and David) and in vivo roles (Yoshida and Cohen) of the lymphokines, with much emphasis placed on the most intensively studied mediator, migration inhibition factor. Other subjects that are well treated include lymphocyte activation (Hirschhorn and Hirschhorn), antigen recognition (Paul and Benacerraf) and reviews of transfer factor