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To the Editor.—
As one of the investigators involved in the studies that failed to demonstrate efficacy for urea in the treatment of the painful crisis of sickle cell anemia, I should like to respond to the letter from Drs. Nalbandian and Henry (229:1285, 1974).Although the Blodgett-Wayne protocol was not followed in every detail for our studies (228:1125, 1974), we did test the hypothesis that rapid elevation of the blood urea concentration to or above a critical level (150 mg/100 ml) would abort a sickle cell painful crisis. The protocol used was based on our own preliminary evaluation begun very soon after Dr. Nalbandian's original studies. Our data suggested that the intravenous urea treatment was worthy of further carefully controlled study (N Engl J Med 285:992, 1971). The Blodgett-Wayne 30% urea solution was connected to a central venous catheter through a Y tube, the other arm of which was
McCurdy PR. Sickle Cell Crisis And Urea. JAMA. 1974;230(10):1386. doi:10.1001/jama.1974.03240100016007