July 3, 1981

Treatment of Heat Stroke With Dantrolene

Author Affiliations

Saint Vincent Hospital and Health Center Billings, Mont

JAMA. 1981;246(1):41-42. doi:10.1001/jama.1981.03320010023020

To the Editor.—  A number of similarities between malignant hyperthermia and heat stroke syndrome exist.1,2 Disorders of electrolyte balance, renal function, bleeding diathesis, plasma enzyme levels, as well as temperature control are common in both syndromes. We recently treated a case of extreme heat stroke syndrome with intravenous (IV) dantrolene sodium, currently the accepted treatment of choice for malignant hyperthermia,2,3 with excellent results. The following is a report on that experience.

Report of a Case.—  A 41-year-old 80-kg man was brought to the emergency room with a rectal temperature greater than 42 °C after working in a hot environment before collapsing.On physical examination, the patient's skin was blotchy, hot, and dry. The respiratory rate was 40 to 45/min, and brachial artery blood pressure was 105/50 mm Hg. Blood was drawn for laboratory studies (Table) followed by rapid intravascular volume expansion (4,000 mL of lactated Ringer's solution over two