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January 13, 1975

Monoclonal IgM Immunoglobulinemia in Psoriatic Arthritis

Author Affiliations

From the Department of Medicine, the Rheumatology and Clinical Immunology Service, Tufts University School of Medicine, Boston. Dr. Lergier is the recipient of a Macy Faculty Fellowship from the Josiah Macy, Jr. Foundation, and is on leave from the Department of Medicine, University of Puerto Rico School of Medicine, San Juan.

JAMA. 1975;231(2):171-173. doi:10.1001/jama.1975.03240140031020

Serum protein electrophoresis in a 61-year-old woman with psoriasis and psoriatic arthritis showed a monoclonal spike that was identified as IgM-k monoclonal immunoglobulinemia by immunodiffusion and immunoelectrophoresis. There was no clinical evidence of myeloma, Waldenström macroglobulinemia, or lymphoma, and the M component has not changed over a three-year observation period. This unusual occurrence may represent another disease entity that may be associated with nonmyelomatous monoclonal immunoglobulinemia.

(JAMA 231:171-173, 1975)