January 20, 1975

Pentazocine-lnduced Fibrous Myopathy

Author Affiliations

From the Department of Neurology (Drs. Oh, Rollins, and Lewis), University of Alabama School of Medicine, and the Veterans Administration Hospital (Dr. Oh), Birmingham, Ala.

JAMA. 1975;231(3):271-273. doi:10.1001/jama.1975.03240150033018

Fibrous myopathy was found in three patients who had taken pentazocine intramuscularly for years. Fibrotic induration in the quadriceps and deltoid muscles, the considerable limitation of motion due to the fibrotic muscle contracture, and the minimal weakness of involved muscles are the most characteristic findings in this condition. Results of animal experiments support the close relationship between myopathy and pentazocine. This serious complication emphasizes more judicious use of pentazocine.

(JAMA 231:271-273, 1975)