January 20, 1975

α1-Antitrypsin Deficiency, Emphysema, Cirrhosis, and Intestinal Mucosal Atrophy

Author Affiliations

From the departments of internal medicine (Drs. Greenwald and Randa) and pathology (Drs. Johnson, Aschenbrener, and Oskvig), University of Iowa Hospitals, Iowa City. Dr. Randa is now with the Department of Neurology, University of Minnesota Hospitals, Minneapolis; Dr. Oskvig is now with the Strong Memorial Hospital, Rochester, NY; Dr. Greenwald is now with the Birmingham Medical Group Clinic, Birmingham, Ala.

JAMA. 1975;231(3):273-276. doi:10.1001/jama.1975.03240150035019

An elderly man with long-standing pulmonary emphysema was seen with recent onset of steatorrhea and ascites. He had very low levels of serum α1-antitrypsin, hepatic cirrhosis, and intestinal mucosal atrophy. We believe that this combination of findings did not occur by chance.

(JAMA 231:273-276, 1975)