An elderly man with long-standing pulmonary emphysema was seen with recent onset of steatorrhea and ascites. He had very low levels of serum α1-antitrypsin, hepatic cirrhosis, and intestinal mucosal atrophy. We believe that this combination of findings did not occur by chance.
(JAMA 231:273-276, 1975)
Greenwald AJ, Johnson DS, Oskvig RM, Aschenbrener CA, Randa DC. α1-Antitrypsin Deficiency, Emphysema, Cirrhosis, and Intestinal Mucosal Atrophy. JAMA. 1975;231(3):273–276. doi:10.1001/jama.1975.03240150035019