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The authors of the first article state that they had two goals in preparing it: (1) to determine from published data whether treatment of various "immunoinflammatory" diseases with nonspecific immunosuppressant nonsteroidal drugs is justified, and (2) to stress the importance of conducting controlled evaluations of such drugs. They summarize numerous reports of therapeutic trials, most of which were uncontrolled, and group them according to the clinical diagnosis, in two tables. The toxic effects of these agents are briefly presented, but no space is given to their pharmacology or cellular effects. The authors conclude that treatment with immunosuppressive drugs "has a vast potential." Primarily, they make a plea that rigorous therapeutic trials be performed to establish the indications for specific agents in specific disease states. Much information is conveniently compressed within these 48 pages, which include a bibliography of 238 references. None are more recent than 1971, which, in a field
Benedek TG. Immunosuppression: Systemic Lupus Erythematosus. JAMA. 1975;231(3):304. doi:10.1001/jama.1975.03240150058035