[Skip to Content]
[Skip to Content Landing]
January 27, 1975

Disseminated Strongyloides stercoralisA Complication of Immunosuppression

Author Affiliations

From the Department of Internal Medicine, the University of Michigan Medical Center, Ann Arbor, and Wayne County General Hospital, Eloise, Mich.

JAMA. 1975;231(4):387-388. doi:10.1001/jama.1975.03240160051024

INCREASING use of immunosuppressive agents for treatment of malignant and nonmalignant disease has brought infection by so-called nonpathogenic organisms to the attention of the clinician. Hyperinfection with Stronglyoides stercoralis has been regarded as an unusual infection in this country. It is often accompanied by bacterial invasion, is seen most commonly in compromised hosts, and is often fatal. The diagnosis is infrequently made before death.

Report of a Case  A 53-year-old man from eastern Kentucky had been well except for hypertension of one year's duration, complicated by intracerebral hemorrhage, obstructive pulmonary disease, and allergy to penicillin. Three months before admission, the diagnosis of renal failure had been made after a renal biopsy specimen disclosed membranoproliferative glomerulonephritis. Treatment with prednisone, 80 mg/day, resulted in improvement.During the week before admission, he had experienced fatigue, crampy abdominal pain, nausea, vomiting, constipation, and a 4-kg (8-lb) weight loss. Medications on admission had included prednisone,