April 21, 1978

Ampicillin Therapy for Pharyngeal Gonorrhea

Author Affiliations

From the Central Venereal Disease Clinic (Drs Di Caprio, Reynolds, and Frank, and Ms Carbone), and the Public Health Laboratory (Mr Nishimura), Santa Clara County Health Department, San Jose, Calif.

JAMA. 1978;239(16):1631-1633. doi:10.1001/jama.1978.03280430047014

Single-dose oral ampicillin trihydrate is ineffective for the treatment of pharyngeal gonorrhea. An evaluation was made of the efficacy of extended oral ampicillin therapy. The regimen consisted of a single oral 3.5-g dose of ampicillin trihydrate and 1.0 g of probenecid on the first day, followed by 500 mg of ampicillin trihydrate four times a day for each of the succeeding two days, for a total ampicillin trihydrate dose of 7.5 g. One or two follow-up cultures taken within 35 days of completion of therapy were obtained in 77 of the 101 patients treated. Positive test-of-cure cultures were reported in three persons, two of whom may have been reinfected. The failure rate was calculated to range between 1.3% (1/77) to 3.9% (3/77). This compares favorably with current recommended modes of therapy.

(JAMA 239:1631-1633, 1978)