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April 21, 1978

Estriol in the Management of the Menopause

Author Affiliations

From the Department of Endocrinology, Medical College of Georgia and The Southeastern Research Foundation, Augusta.

JAMA. 1978;239(16):1638-1641. doi:10.1001/jama.1978.03280430054016

Estriol was administered for a six-month period as estrogen replacement therapy to 52 symptomatic postmenopausal women. Assays of serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), estrone, and estradiol were performed before and during therapy. During this period of administration, vaginal cytology, cervical mucus, and endometrial studies were performed. Clinical effectiveness was directly related to dosage (2 to 8 mg/day). Estriol (8 mg/day) failed to induce endometrial proliferation and proved a poor suppressor of FSH and LH. This agent's capacity to relieve vasomotor instability and improve vaginal maturation without notable side effects is sufficient reason to include this drug in the management of the postmenopausal syndrome.

(JAMA 239:1638-1641, 1978)