THERE has been a substantial increase in the frequency of adenomas of the liver in young women in the last few years. A large number of these women have been taking long-term oral contraceptives. With increased awareness of this problem, more asymptomatic women are being detected. The opinion concerning the surgical approach for an asymptomatic intrahepatic adenoma has varied mainly because of the lack of information regarding its natural history, the uncertainty of resolution after hormone withdrawal, and the fear of spontaneous hemorrhage.
The evidence correlating oral contraceptive use and the onset of liver tumors has been circumstantial, and there have been reports of these tumors occurring in patients who do not take oral contraceptives. This case, in addition to others described recently showing tumor regression following the withdrawal of oral contraceptive use, lends more support to the etiologic role of oral contraceptives in these tumors.
Report of a Case
Ramseur WL, Cooper MR. Asymptomatic Liver Cell AdenomasAnother Case of Resolution After Discontinuation of Oral Contraceptive Use. JAMA. 1978;239(16):1647–1648. doi:10.1001/jama.1978.03280430063019