Experience with chymopapain chemonucleolysis in 1,200 cases of lumbar disk disease indicates that it is an effective method of relieving pain resulting from an abnormal intervertebral disk. Complications were few; anaphylaxis occurring immediately after injection was by far the most serious. With the use of a corticosteroid and an antihistamine in preoperative preparation, the incidence of anaphylaxis has dropped, although it still occurs. On long-term follow-up, chemonucleolysis appears to be as good as laminectomy in properly selected cases.
(JAMA 231:474-479, 1975)
Wiltse LL, Widell EH, Yuan HA. Chymopapain Chemonucleolysis in Lumbar Disk Disease. JAMA. 1975;231(5):474–479. doi:10.1001/jama.1975.03240170016008