Oral contraceptive use alone, in the absence of smoking, hypertension, or migraine, significantly increases the risk of stroke. Regardless of use or nonuse of these agents, hypertension is a risk factor for development of either thrombotic or hemorrhagic stroke. Regular cigarette smoking and a history of symptoms indicative of migraine also increase the likelihood of one or the other type of stroke, but more information is needed before a definite relationship can be established between these clinical factors and cerebrovascular disease.
(JAMA 231:718-722, 1975)
Oral Contraceptives and Stroke in Young WomenAssociated Risk Factors. JAMA. 1975;231(7):718-722. doi:10.1001/jama.1975.03240190022010