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July 24, 1981

First-Trimester Drug Use and Congenital Disorders

Author Affiliations

From the Boston Collaborative Drug Surveillance Program, Boston University Medical Center, Waltham, Mass (Dr Jick); the Group Health Cooperative of Puget Sound, Seattle (Ms Hunter, Ms Madsen, and Dr Stergachis); and the EmbryologyTeratology Unit, Children's Service, Massachusetts General Hospital, Boston (Dr Holmes).

JAMA. 1981;246(4):343-346. doi:10.1001/jama.1981.03320040015021

We determined the prevalence of certain major congenital disorders among the infants of women who used a wide variety of drugs during the first trimester of pregnancy in a prepaid health plan in which automated recording of prescriptions filled and disorders diagnosed at birth was available. No strong associations between any of the commonly used drugs and congenital disorders studied were present.

(JAMA 1981;246:343-346)