March 3, 1975

Physostigmine Salicylate in the Treatment of Tricyclic Antidepressant Overdosage

Author Affiliations

From the Regional Poisoning Treatment Centre, Royal Infirmary, Edinburgh. Dr. Newton is now with Ninewells Hospital, Dundee, Scotland.

JAMA. 1975;231(9):941-943. doi:10.1001/jama.1975.03240210021012

Following intravenous administration of physostigmine salicylate for tricyclic antidepressant poisoning in 21 patients, convulsions occurred in two patients, and severe cholinergic manifestations occurred in two others. Because of these untoward effects and the very short duration of its beneficial action, it is very doubtful that physostigmine has any place in the routine management of tricyclic antidepressant poisoning.

(JAMA 231:941-943, 1975)