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March 10, 1975

Cryptococcus neoformans as a Cause of Lytic Bone Lesions

Author Affiliations

From the Division of Infectious Diseases (Drs. Burch and Quinn) and the Department of Pathology (Drs. Fine and Eisses), Henry Ford Hospital, Detroit.

JAMA. 1975;231(10):1057-1059. doi:10.1001/jama.1975.03240220037017

Cryptococcosis is a disseminated infection of man and animals that involves many organs, especially the central nervous system. Isolated bone involvement may cause lytic bone lesions. Diagnosis may be made by pathologic sections and culture of specimens obtained through surgical biopsy. When Cryptococcus is recovered from bone, care must be taken to study other organ systems, especially the central nervous system. Isolated bone disease without meningitis is very uncommon. Intense medical therapy is necessary for treatment of meningitis; isolated osteomyelitis may respond to surgical drainage alone.

(JAMA 231:1057-1059, 1975)