Cryptococcosis is a disseminated infection of man and animals that involves many organs, especially the central nervous system. Isolated bone involvement may cause lytic bone lesions. Diagnosis may be made by pathologic sections and culture of specimens obtained through surgical biopsy. When Cryptococcus is recovered from bone, care must be taken to study other organ systems, especially the central nervous system. Isolated bone disease without meningitis is very uncommon. Intense medical therapy is necessary for treatment of meningitis; isolated osteomyelitis may respond to surgical drainage alone.
(JAMA 231:1057-1059, 1975)
Burch KH, Fine G, Quinn EL, Eisses JF. Cryptococcus neoformans as a Cause of Lytic Bone Lesions. JAMA. 1975;231(10):1057–1059. doi:10.1001/jama.1975.03240220037017