Two patients with pheochromocytoma developed symptoms and signs of peripheral vascular disease, and in both cases, all peripheral pulses were palpable. At autopsy, no anatomical changes in the peripheral blood vessels could be found. These findings support the hypothesis that the circulatory changes were caused by excessive secretion of catecholamines. Symptoms and signs of peripheral vascular disease in the presence of palpable pulses in a hypertensive patient should raise the suspicion of pheochromocytoma.
Scharf Y, Nahir M, Plavnic Y, Ben-Arieh J, Lichtig C, Gellei B. Intermittent Claudication With Pheochromocytoma. JAMA. 1971;215(8):1323-1324. doi:10.1001/jama.1971.03180210067019