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To the Editor.—
In "The Use of Factor VIII and Factor IX Concentrates During Surgery" by George and Breckenridge (214:1673-1676, 1970) the authors tell of highly successful results with 14 hemophiliac patients, but omit giving the protective therapy. There is only the mere statement that specific concentrates were used. How much? How often? At what cost? What was their source, the institutional blood bank or commercial firms? Any reactions? Preventive methods used to forestall reactions? How frequently were the factor levels on the blood titrated? Any development of inhibitors?
Wolman IJ. Factor VIII and Factor IX Concentrates in Surgery In Hemophilia. JAMA. 1971;215(8):1328. doi:10.1001/jama.1971.03180210072029