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To the Editor.—
Wolman's letter to the editor suggests that Dr. George and I did not express the thesis of our manuscript in clear enough terms, since this paper was not intended as a "how to do it" study. It was written to suggest that a more liberal approach to the treatment of hemophilia may be appropriate in the modern era of concentrated clotting factors.The methods used for assay of the various clotting factors and calculation of the plasma volume, clotting factor levels, and half-lives are adequately referenced in the manuscript and are surely quite familiar to most hematologists who care for patients with bleeding disorders. We therefore felt it would be redundant to include a large method section in what was meant to be a brief communication.In answer to the question concerning the concentrates used, the manuscript clearly states which "concentrates" were used. They were purchased from
Breckenridge RT. Factor VIII and Factor IX Concentrates in Surgery In Hemophilia. JAMA. 1971;215(8):1328. doi:10.1001/jama.1971.03180210072030