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March 24, 1975

Polyarthritis Associated With Clindamycin-lnduced Colitis

Author Affiliations

University of Kansas Medical Center Kansas City

JAMA. 1975;231(12):1228. doi:10.1001/jama.1975.03240240008004

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To the Editor.—  In their article, Cohen et al (223:1379, 1973) described pseudomembranous colitis following therapy with clindamycin hydrochloride. Despite the association of arthritis with inflammatory intestinal disease, there are no reports in the literature of arthritis occurring with antibiotic-induced colitis. We would like to report a case of pseudomembranous colitis with acute migratory polyarthritis following therapy with clindamycin.

Report of a Case.—  A 55-year-old man with no previous history of intestinal or arthritic disease had nonspecific sialadenitis and was treated for 12 days with clindamycin hydrochloride, 150 mg orally four times a day. During the course of therapy, he had two to three loose stools per day, increasing to eight to ten watery, mucoid, nonbloody stools daily. This persisted for four weeks. Twenty-seven days after stopping clindamycin therapy, when his diarrhea was most severe, he had an acute migratory polyarthritis involving the shoulders, elbows, knees, ankles, and the metacarpophalangeal