Cardiovascular abnormalities developed in a patient during a proteinsparing modified fasting diet. Syncope was the complaint at the time of examination. Hypotension, persistent QTc interval prolongation, and a low QRS voltage were observed before the development of refractory ventricular tachycardia. At autopsy, antemortem thrombi were attached to the left ventricular endocardium and a fenestrated aortic valvule. Strick proteinsparing modified fasting is not without risk of sudden death even with close medical supervision.
(JAMA 240:120-122, 1978)
Brown JM, Yetter JF, Spicer MJ, Jones JD. Cardiac Complications of Protein-Sparing Modified Fasting. JAMA. 1978;240(2):120-122. doi:10.1001/jama.1978.03290020042020