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July 21, 1978

High Fiber Diet in HyperlipemiaComparison With Cholestyramine Treatment in Type Ila Hyperlipoproteinemia

Author Affiliations

From the Department of Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minn.

JAMA. 1978;240(3):223-227. doi:10.1001/jama.1978.03290030041016

Fourteen patients with type Ila hyperlipoproteinemia were treated with a high fiber intake (powdered cellulose or soy hulls or both) for six months. Eight of the patients were treated with 16 g of cholestyramine resin daily without the high fiber intake for an additional six months. The cholesterol intake was comparable in both treatment programs. The mean serum cholesterol levels decreased during both, but the decrease occurred and was more pronounced in all patients treated with cholestyramine. Responsiveness to the high fiber diet was not related to an increased responsiveness to cholestyramine treatment. In most patients the serum triglyceride levels increased, and the fasting plasma glucose level did not change substantially during either treatment program. Both regimens were free of adverse side effects.

(JAMA 240:223-227, 1978)