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July 28, 1978

Crohn's Disease: Aetiology, Clinical Manifestations and Management

Author Affiliations

University of Missouri School of Medicine Columbia


by Bryan N. Brooke et al, 113 pp, with illus, $21, New York, Oxford University Press, 1977.

JAMA. 1978;240(4):393. doi:10.1001/jama.1978.03290040071033

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


The etiology of Crohn's disease is still unknown; the pathology of the disease is becoming better and better understood; specific therapies are elusive, although recent clinical trials indicate that benefit can be expected in at least some of the cases of the disease.

In this brief volume, the current status of Crohn's disease is well described. The authors are among the most authoritative of all the persons working in the field. Their expertise ranges from basic experimental pathology to a broad understanding of clinical management of this complex disorder, and they have been erudite and fair in their presentation of the material. Especially valuable is their discussion of the current status of work toward the possibility of an infectious cause for the disease.

One major flaw detracts from the volume, however. The actual text pages of the book number 93. Of these, the authors have devoted 11 pages to a