Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
August 4, 1978

Intrathecal Gentamicin for Refractory Gram-Positive Meningitis

Author Affiliations

From the Department of Medicine, Johns Hopkins University School of Medicine, Baltimore.

JAMA. 1978;240(5):469-471. doi:10.1001/jama.1978.03290050059024

The mortality for meningitis due to Staphylococcus aureus or Listeria monocytogenes remains high, ranging from 32% to 77%. We treated a patient with staphylococcal meningitis refractory to methicillin sodium and oxacillin sodium, and a patient with Listeria meningitis refractory to penicillin G potassium and ampicillin sodium; both patients were cured when intrathecal gentamicin sulfate was added to the regimen. The combination of intrathecal gentamicin and a penicillin may be beneficial in refractory staphylococcal or Listeria meningitis.

(JAMA 240:469-471, 1978)