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September 15, 1978

Association of Acromegaly and Meningiomas

Author Affiliations

From the Division of Endocrinology and Metabolism, Hahnemann Medical College and Hospital, Philadelphia.

JAMA. 1978;240(12):1267-1268. doi:10.1001/jama.1978.03290120061030

THE SIMULTANEOUS occurrence of an intracranial meningioma and a pituitary adenoma is exceedingly rare, with only six cases previously reported.1-2 In two of those cases, both tumors were present before therapy. Since the meningiomas developed after radiation therapy in the other four cases, the possibility must be considered that growth hormoneproducing pituitary tumors facilitate the development of meningiomas. We report the coexistence of a growth hormone-producing pituitary tumor and a subfrontal meningioma at the time of initial diagnosis.

Report of a Case  A 57-year-old man was admitted to Hahnemann Medical College and Hospital for evaluation of an abnormal skull roentgenogram and acromegalic features. The patient had intermittent right-sided headaches unaccompanied by change in vision, nausea, or vomiting precipitated by anxiety. For many years, these were promptly relieved by acetaminophen.Though his hands had always been large, his feet had increased in size during the years. He denied any change