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July 25, 1986

The Effect of Prostate Aspiration Biopsy on Serum Levels of Prostatic Acid Phosphatase and Prostate-Specific Antigen

Author Affiliations

Hôpital de l'Antiquaille Lyon, France

JAMA. 1986;256(4):474. doi:10.1001/jama.1986.03380040048026

To the Editor. —  Metastatic invasion is correlated with elevated prostatic acid phosphatase (PAP) levels in 98% of patients with prostatic adenocarcinoma,1 and PAP therefore is considered to be a reliable index of metastatic invasion. A new biologic marker for follow-up and assessment of therapeutic efficacy in prostate cancers has recently been identified: prostate-specific antigen (PA).2 In studying the value of prostatic aspiration biopsy in the diagnosis of adenocarcinoma, we noticed a transitory abnormally increased PAP serum level in many patients without cancer. We report herein a study of the influence of prostatic aspiration biopsy on serum levels of PAP and the new marker, PA.

Patients and Methods.—  Fourteen patients (eight with prostatic adenoma and six with prostatic adenocarcinoma) were subjected to transperineal prostatic aspiration biopsy using a needle (Tru-cut) of the Ducrot de Montera type. Blood from these patients was sampled 20 minutes before and 20 minutes