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July 25, 1986

Bone Marrow Disorders: The Biological Basis of Clinical Problems

Author Affiliations

University of South Carolina Columbia

JAMA. 1986;256(4):533. doi:10.1001/jama.1986.03380040107044

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


This book is exactly what the title says it is, ie, a discussion of hemopoietic disorders from a biologic perspective. The uniqueness of the book relates to the emphasis placed by the authors on the use of the in vitro cell culture technique in describing normal and abnormal aspects of hemopoiesis. It is decidedly not the usual atlas of bone marrow abnormalities emphasizing morphologic (both light and electron microscopic photographs) and cytochemical descriptors. The absence of color plates underscores this difference. A small number of black-and-white photographs and line drawings accomplish the graphic needs of the text.

The authors have aimed the book at two slightly disparate audiences. They want to provide clinicians with information about the experimental basis for the conditions they treat, emphasizing use of the in vitro cell culture technique. For researchers, they want to provide an outline of practical problems with which the clinician deals. They