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January 12, 1994

Pneumocystis carinii Pneumonia in Children With Perinatally Acquired HIV Infection

Author Affiliations

Jefferson Medical College Philadelphia, Pa

JAMA. 1994;271(2):102. doi:10.1001/jama.1994.03510260026013

To the Editor.  —We read with interest the study by Simonds et al,1 which further defines the epidemiology and risk of occurrence of Pneumocystis carinii pneumonia (PCP) in children with perinatally acquired human immunodeficiency virus (HIV) infection. In their study, the median survival after diagnosis of PCP was 19 months, which is substantially longer than has been noted in previous reports.2-4 Moreover, their data did not demonstrate a significant difference in survival for infants (<1 year old) compared with older children who had PCP.Our data,5 generated from longitudinal histories of 789 New York State Medicaid-enrolled children (1983 to 1990), documented a median survival of 9 months in children younger than 13 years who had PCP as their initial acquired immunodeficiency syndrome (AIDS)-defining condition. A significantly shorter survival was noted for infants younger than 6 months compared with older children, regardless of the AIDS-defining diagnosis. In an

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