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This is not a book for the uninitiated but rather for those with a basic familiarity with the facts of brain embryology, the anatomic/developmental stages of the brain, the experimentally determined functional localizations in the brain, and the mechanisms and roles of the neurotransmitters. For those so equipped, it can provide many useful insights. It is not easy to read because of the concentrated argument that it presents and the psychoanalytic terminology it uses. It is speculative, for although the bases from which the author writes are now in rough outline the synthesis of anatomic cortical development, epigenesis, and the various roles of the transmitters are not precisely known at this time. The author effectively uses the available data in all of these areas as well as the work of Brazelton, Piaget, Luria, and Vygotsky.
An important postulate for the author's thesis on the nature of the mental disorders is
Craig JM. Clinical Neuroscience: From Neuroanatomy to Psychodynamics. JAMA. 1986;256(9):1202. doi:10.1001/jama.1986.03380090142037