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September 19, 1986

Pregnancy and Delivery in Two Women With Ovarian Failure Following Nonsurgical Transfer of In Vivo Fertilized Uterine Ova

Author Affiliations

Graziella Formigli Toxicology Unit University of Pavia Medical School Pavia, Italy Fertility and Genetics Research, Inc Chicago

JAMA. 1986;256(11):1442. doi:10.1001/jama.1986.03380110048011

To the Editor.—  We wish to report a first birth and a viable ongoing pregnancy in each of two women who had no ovarian function. The pregnancies followed nonsurgical recovery of in vivo fertilized uterine ova obtained from fertile donors and transfer of these concepti to the uteri of the two women.

Report of Cases.—  A healthy 2300-g male infant was delivered by cesarean section at 33 weeks' gestation because of suspected intrauterine growth retardation to a 27-year-old woman, gravida 0, who had a history of amenorrhea following oophorectomy at the age of 17 years. The newborn is thriving and breast-feeding normally. The second pregnancy, uneventful thus far, occurred in a 37-year-old woman, gravida 0, with a 20-year history of amenorrhea diagnosed as premature ovarian failure. In both women, diagnoses were confirmed by menopausal levels of follicle-stimulating hormone, luteinizing hormone, and estradiol.Both mothers were treated one month before the