Because only 9.4% of depressions are recognized at initial evaluation by primary physicians, the diagnosis of depression is important. Forty percent of a group of mixed depressions will resolve in a month without treatment, and 70% will resolve with the use of tricyclic antidepressants. Research on plasma levels of tricyclic antidepressants suggests new clinical strategies for adjusting dosages; neurochemical studies may provide an appropriate selection process for choosing a tricyclic antidepressant.
(JAMA 240:2264-2266, 1978)
Cutler NR, Heiser JF. The Tricyclic Antidepressants. JAMA. 1978;240(21):2264–2266. doi:10.1001/jama.1978.03290210046023