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October 3, 1986

Cardiopulmonary Resuscitation

JAMA. 1986;256(13):1722. doi:10.1001/jama.1986.03380130050011

To the Editor.—  In the "Standards and Guidelines for Cardiopulmonary Resuscitation (CPR) and Emergency Cardiac Care (ECC),"1 the following errors were noted. On page 2941, the authors state that one ampule (400 mg) of dopamine hydrochloride, when mixed in 250 mL, produces a concentration of 800 μg/mL. Actually, the above formulation produces a concentration of 1600 μg/mL. The authors go on to say that 2-mg vials of nitroglycerin, when diluted in 250 mL, result in a concentration of 80 μg/mL. This would actually yield a concentration of 8 μg/mL. Finally, the authors give the initial dose of sodium nitroprusside as 10 to 20 mg/min. Such a regimen would cause a 70-kg patient to receive 20 to 30 times the maximum recommended dose, according to current product prescribing information (dosage range, 0.5 to 10 μg/kg/min).While such inadvertent manuscript errors might be considered trivial in the general medical literature, they