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October 3, 1986

Sites of Rhinovirus Recovery After Point Inoculation of the Upper Airway

Author Affiliations

From the Otopathological Laboratory, Department of Otorhinolaryngology, Rigshospitalet, University of Copenhagen (Drs Winther and Mygind); the Departments of Internal Medicine (Dr Gwaltney) and Pediatrics (Dr Hendley), University of Virginia School of Medicine, Charlottesville; and the Departments of Pathology and Pediatrics, University of Utah College of Medicine, Salt Lake City (Dr Turner).

JAMA. 1986;256(13):1763-1767. doi:10.1001/jama.1986.03380130091034

Spread of rhinovirus infection in the nose was studied after point inoculation of 25 μL of rhinovirus suspension either under the right inferior turbinate via the test duct (26 volunteers) or onto the posterior nasopharyngeal wall (through the mouth under direct vision) (six volunteers). Epithelial brush samples obtained daily from the anterior and posterior portions of the inferior turbinate in both nasal cavities and the nasopharynx were cultured for rhinovirus. Point inoculation of rhinovirus produced a high infection rate, but the entire nasal lining was not infected at the time of peak symptoms. Virus was usually first detected at the nasopharyngeal site, with subsequent spread of infection anteriorly to one or both inferior turbinates. Spread to the left turbinate was not detected in seven of 17 volunteers during the first five days after right eye inoculation. Virus recovery from the mucosa declined by day 16 and ceased by day 21.

(JAMA 1986;256:1763-1767)