[Skip to Content]
[Skip to Content Landing]
October 24, 1986

Eflornithine Treatment of Pneumocystis carinii Pneumonia in AIDS

Author Affiliations

University of Southern California Schools of Medicine and Pharmacy Los Angeles

JAMA. 1986;256(16):2197-2198. doi:10.1001/jama.1986.03380160055013

To the Editor.—  We have treated Pneumocystis carinii pneumonia (PCP) with the investigational drug eflornithine (α-difluoromethylornithine) in ten patients with acquired immunodeficiency syndrome (AIDS). Eflornithine irreversibly inhibits ornithine decarboxylase and prevents the biosynthesis of putrescine and other polyamines neces