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November 7, 1986

Polymyositis Associated With AIDS Retrovirus

Author Affiliations

From the National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Md (Drs Dalakas, Gravell, and Sever); and the Armed Forces Institute of Pathology, Washington, DC (Dr Pezeshkpour).

JAMA. 1986;256(17):2381-2383. doi:10.1001/jama.1986.03380170097026

Two homosexual men were initially seen with polymyositis as the only manifestation of the acquired immunodeficiency syndrome (AIDS) retrovirus infection. They developed AIDS-related complex a few weeks later and typical AIDS two to six months after onset of muscle weakness. By use of anti-human T-cell lymphotropic virus type III antiserum and monoclonal antibodies to lymphocyte subsets in an immunofluorescence technique, viral antigens were found in the OKT4-positive lymphoid cells surrounding muscle fibers and invading the endomysia septa. We concluded that an initial infection with the AIDS retrovirus can be associated with polymyositis, which may be the first clinical manifestation of an impending AIDS-related complex or AIDS.

(JAMA 1986;256:2381-2383)